Recrystallized HI-6 dimethylsulfate
AssigneeSouthwest Research Institute
InventorsShawn T. Blumberg, Paul W. Miguel
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Abstract
The present invention is directed at the synthesis and characterization of recrystallized HI-6 dimethylsulfate (DMS). The method can comprise dissolving HI-6 DMS in an alkyl-based glycol and adding an antisolvent to recrystallize HI-6 DMS or dissolving HI-6 DMS in methanol and adding dimethoxy ethane or dimethyl formamide as the antisolvent to recrystallize HI-6 DMS. The recrystallized HI-6 DMS indicates a resistance to moisture absorption and/or a DSC melting point onset (MP Onset) at least at or above 160.0° C.
Claims5
A method for making a solvate and hydrate of (1-(2-(hydroxyiminomethyl)pyridinium)-3-(4-carbamoylpyridinium)-2-oxapropane) dimethanesulfonate comprising:
- dissolving (1-(2-(hydroxyiminomethyl)pyridinium)-3-(4-carbamoylpyridinium)-2-oxapropane) dimethanesulfonate in an alkyl-based glycol comprising ethylene glycol or 1,2-propane diol and adding an antisolvent comprising tert-butanol to make a solvate and hydrate of (1-(2-(hydroxyiminomethyl)pyridinium)-3-(4-carbamoylpyridinium-2-oxapropane) dimethanesulfonate wherein said solvate and hydrate of (1-(2-(hydroxyiminomethyl)pyridinium)-3-(4-carbamoylpyridinium)-2-oxapropane) does not absorb water over a seven-day period under ambient temperature and humidity conditions.
Dependencies are inferred from the claim text.