Treatment of anthrax with pegylated capsule-degrading enzyme
AssigneeThe Government of the United States of America, as represented by the Secretary of the Navy
InventorsPatricia M. Legler, Arthur M. Friedlander, Jaimee R. Compton
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Abstract
A pegylated, circularly permuted construct of the CapD enzyme (a gamma glutamyl transferase enzyme acting as a hydrolase specific to poly-γ-D-glutamic acid) is used to treat anthrax and other bacterial infections, including but not limited to infection with strains that are resistant to available antibiotics.
Claims5
A method of treating an infection of bacteria in a subject in need thereof, the method comprising:
- administering a pegylated protein comprising SEQ ID NO:
- 2, SEQ ID NO:
- 3, SEQ ID NO:
- 4, or SEQ ID NO:
- 5 to the subject,
- wherein the bacteria has a capsule and is Bacillus anthracis or Staphylococcus epidermidis.
A method of treating anthrax in a subject in need thereof, the method comprising administering a pegylated protein comprising SEQ ID NO:
- 2, SEQ ID NO:
- 3, SEQ ID NO:
- 4, or SEQ ID NO:
- 5 to the subject.
Dependencies are inferred from the claim text.