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US 11,986,521 B2Granted
Viral particle-based vaccine
AssigneeVakzine Projekt Management GmbH
InventorsBodo Plachter, Inessa Penner
Life of this patent
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Abstract
The present invention relates to nucleic acid molecules encoding a recombinant human cytomegalovirus (HCMV) strain, dense bodies produced by said HCMV strain and preparations of said dense bodies for use in medicine, particularly as a vaccine against HCMV.
Claims18
A nucleic acid molecule encoding the genome of a recombinant human cytomegalovirus (HCMV) Towne strain, wherein the Towne strain sequence of SEQ ID NO:
- 6 is modified to comprise the elements necessary to express the genome as a Bacterial Artificial Chromosome (BAC), wherein the recombinant HCMV comprises an open reading frame (ORF) encoding Green Fluorescent Protein (GFP) which is disrupted by the insertion of a gene heterologous to HCMV Towne strain, wherein the recombinant HCMV encodes a functional heterologous UL130 protein, and wherein the nucleic acid molecule has an identity of at least 90% when compared to the genome of the HCMV strain Towne as deposited under GenBank accession no:
- AY315197 (SEQ ID NO:
- 6).
A vector comprising a nucleic acid molecule encoding the genome of a recombinant human cytomegalovirus (HCMV) Towne strain, wherein the Towne strain sequence of SEQ ID NO:
- 6 is modified to comprise the elements necessary to express the genome as a Bacterial Artificial Chromosome (BAC), wherein the recombinant HCMV comprises an open reading frame (ORF) encoding Green Fluorescent Protein (GFP) which is disrupted by the insertion of a gene heterologous to HCMV Towne strain, wherein the recombinant HCMV encodes a functional heterologous UL130 protein, and wherein the nucleic acid molecule has an identity of at least 90% when compared to the genome of the HCMV strain Towne as deposited under GenBank accession no:
- AY315197 (SEQ ID NO:
- 6).
Dependencies are inferred from the claim text.