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US 11,986,480 B2Granted
Heterocyclic compound
AssigneeTohoku University
InventorsHirokazu Arimoto, Kaori Itto, Daiki Takahashi, Nobuo Cho, Hiroshi Nara, Kenichiro Shimokawa, Taiichi Ohra, Shigekazu Sasaki, Naoki Ishii
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Abstract
Provided is a novel compound or salt thereof that induces degradation by autophagy of an intracellular molecule. In this compound, a ligand having activity to bind to an intracellular molecule and a structure having activity to induce autophagy of an intracellular molecule are linked via a linker without loss of the activity of the ligand and the structure.
Claims13
A compound or a salt thereof, the compound being represented by the following formula (I):
- wherein
- R1 represents a halogenated C1-C12 alkoxy group,
- La represents a bond or a chain linker having 1 to 10 atoms in a backbone,
- Lb represents
- i) a bond,
- ii) a chain linker having 1 to 13 atoms in a backbone, or
- iii) formula (II)
- wherein L1 represents a bond or a chain linker having 1 to 10 atoms in a backbone,
- X1 represents an optionally substituted divalent cyclic group, and
- L2 represents a bond or a chain linker having 1 or 2 atoms in a backbone, and
- R2 represents a group selected from the following formulas:
- wherein
- RA1, RA2, RA3, RA4, RA5, and RA6 each independently represent a hydrogen atom or a substituent,
- RB1, RB2, and RB3 each independently represent an optionally substituted hydrocarbon ring group, an optionally substituted unsaturated heterocyclic group, or —X2—R3,
- wherein X2 represents an optionally substituted methylene group, and R3 represents an optionally substituted cyclic group.
12 more elements
Dependencies are inferred from the claim text.