Composite scaffold for the repair, reconstruction, and regeneration of soft tissues
AssigneeBiorez, Inc.
InventorsKevin A. Rocco, Bhavana Mohanraj, Jeffrey Ott, Justin Bendigo, Jacob Edward Komenda, Mark Theodore Aronson, Andrew James Carter
Life of this patent
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Abstract
A composite scaffold having a highly porous interior with increased surface area and void volume is surrounded by a flexible support structure that substantially maintains its three-dimensional shape under tension and provides mechanical reinforcement during repair or reconstruction of soft tissue while simultaneously facilitating regeneration of functional tissue.
Claims32
A composite scaffold comprising:
- a microporous matrix having a multitude of interconnected pores opening to an exterior surface of the microporous matrix and collectively defining void space;
- and
- a three-dimensional, textile structure supporting the microporous matrix and comprising first and second outer layers separated by an interior space therebetween and the microporous matrix within the interior space, and a plurality of spacer yarns extending through the interior space and attached to each of the first and second outer layers;
- wherein a surface area of the composite scaffold is between approximately 0.3 m2/gram and 15.0 m2/gram per gram of the composite scaffold.
A composite scaffold having a volume and a surface area and comprising:
- a microporous matrix having a multitude of interconnected pores collectively defining void space opening to an exterior surface of the microporous matrix;
- and
- a three-dimensional, textile structure supporting the microporous matrix and comprising first and second outer layers separated by an interior space therebetween and the microporous matrix within the interior space, and
- a plurality of spacer yarns extending through the interior space and attached to each of the first and second outer layers will;
- wherein the composite scaffold has a permeability of between approximately 1200 and 3000 millidarcy.
A composite scaffold comprising:
- a microporous matrix having a multitude of interconnected pores opening to an exterior surface of the microporous matrix and collectively defining void space having a void space volume;
- and
- a three-dimensional, textile structure supporting the microporous matrix and comprising first and second outer layers separated by an interior space therebetween and the microporous matrix disposed within the interior space, and
- a plurality of spacer yarns extending through the interior space and attached to each of the first and second outer layers;
- wherein the multitude of interconnected pores have a tortuosity of approximately between 1 μm/μm and 50 μm/μm, wherein the tortuosity defines a ratio of actual flow path length to straight distance between first and second ends of the microporous matrix.
A composite scaffold comprising:
- a three-dimensional, textile support structure comprising first and second outer layers defining an interior space therebetween and separated by the interior space, and further comprising a plurality of spacer yarns extending through the interior space and attached to each of the first and second outer layers;
- and
- a microporous matrix disposed within the interior space of the support structure,
- wherein the microporous matrix comprises a plurality of interconnected pores having a median pore size of between approximately 10 μm to 100 μm.
Dependencies are inferred from the claim text.