US 11,982,655 B2Granted

Analysis apparatus having a plurality of liquid chromatographs and its analysis method

AssigneeHitachi High-Tech Corporation

InventorsDaisuke Akieda, Makoto Nogami, Iwao Suzuki, Masako Kawarai, Izumi Ogata, Shinya Ito

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Abstract

The present invention makes it possible to realize an analysis apparatus having a plurality of liquid chromatographs capable of judging separation performance and the like at the right timing and improving analysis performance early. Analysis starts and a mixed sample is prepared by adding a non-retaining ingredient to a measurement object sample and is introduced into an analysis flow path (S401 to S404). The mixed sample is separated into components by a separation column, the components are outputted as chromatogram data by a detector, and the analysis finishes (S404 to S406). Retention time and peak information are acquired from the chromatogram outputted from the detector, whether or not a measurement result is within an allowable range is judged, and the process shifts to next analysis when the measurement result is within the allowable range (S407 to S409). An amount of transit time t0 of a non-retaining ingredient shifted from an allowable value is confirmed when separation performance is outside an allowable range at step S408 and a separation column replacement instruction is outputted to an output unit when fluctuation of the transit time t0 is within an allowable range (S410, S411). A device maintenance instruction is outputted to the output unit when the fluctuation is outside the allowable range at step S410 (S412).

Claims11

Dependent claims

An analysis apparatus having a plurality of liquid chromatographs, comprising:

the multiple liquid chromatographs each of which comprises a separation column to receive a sample and separate the received same into components;
a detector to detect the components of the sample fed from each of the multiple liquid chromatographs;
a data processing unit to process detection data detected by the detector;
a device control unit to control the multiple liquid chromatographs and the detector;
and
an output unit,
wherein the device control unit judges a device status of the multiple liquid chromatographs in accordance with data that is obtained by detecting a measurement object sample and a non-retaining ingredient sample introduced into any one of the multiple liquid chromatographs by the detector and that is processed by the data processing unit;
wherein the device control unit judges a device status of the multiple liquid chromatographs on the basis of peak separation performance of the measurement object sample and fluctuation of retention time of the non-retaining ingredient sample;
wherein the device control unit judges whether or not peak separation performance of the measurement object sample is within a peak separation allowable range, outputs a separation column replacement instruction to the output unit when fluctuation of retention time of the non-retaining ingredient sample is within a fluctuation allowable range, and outputs a device maintenance instruction to the output unit when the peak separation performance is not within the peak separation allowable range and the fluctuation of the retention time of the non-retaining ingredient sample is not within the fluctuation allowable range.

6 more elements

An analysis method of a plurality of liquid chromatographs, comprising the multiple liquid chromatographs each of which has a separation column to receive a sample and separate the received sample into components, a detector to detect the components of the sample fed from each of the multiple liquid chromatographs, a data processing unit to process detection data detected by the detector, and a device control unit to control the multiple liquid chromatographs and the detector,

the analysis method comprising the steps of:
detecting a measurement object sample and a non-retaining ingredient sample introduced into any one of the multiple liquid chromatographs and not retained in the separation column by the detector;
judging a device status of the multiple liquid chromatographs on the basis of peak separation performance of the measurement object sample and fluctuation of retention time of the non-retaining ingredient sample;
judging whether or not peak separation performance of the measurement object sample is within a peak separation allowable range;
outputting a separation column replacement instruction to an output unit when fluctuation of retention time of the non-retaining ingredient sample is within a fluctuation allowable range;
and
outputting a device maintenance instruction to the output unit when the peak separation performance is not within the peak separation allowable range and the fluctuation of the retention time of the non-retaining ingredient sample is not within the fluctuation allowable range.

4 more elements

Dependencies are inferred from the claim text.