Real-time, non-destructive Container Closure Integrity measurement

A method of configuring, validating, or monitoring a filling line for container systems, at least one container system of the container systems comprising a container, an elastomeric stopper comprising an embedded positioning component, a retainer for retaining the elastomeric stopper, and a cap comprising at least a portion of a detection system for detecting a position of the embedded positioning component, wherein the elastomeric stopper is confined between a rim of the container and the retainer to seal the container, the method comprising:

• filling and sealing the container of the at least one container system;
• determining, using the detection system, the position of the embedded positioning component;
• and
• determining, based on the position of the embedded positioning component, closure integrity of the at least one container system.

A method of configuring, validating, or monitoring a filling line for container systems, at least one container system of the container systems comprising a container, an elastomeric stopper, a retainer for retaining the elastomeric stopper, a force sensitive resistor between the elastomeric stopper and the retainer, and a cap comprising at least a portion of a detection system for detecting a resistance of the force sensitive resistor, wherein the elastomeric stopper is confined between a rim of the container and the retainer to seal the container, the method comprising:

• filling and sealing the container of the at least one container system;
• measuring, with the detection system, the resistance of the force sensitive resistor;
• and
• determining closure integrity of the container system based on the resistance.

A container system comprising:

• a seal;
• a container;
• an elastomeric stopper comprising an embedded positioning component;
• a retainer for retaining the elastomeric stopper between the retainer and a rim of the container;
• and
• a cap comprising at least a portion of a detection system for detecting a position of the embedded positioning component,
• wherein the embedded positioning component comprises at least one of a magnetic material or an electrically conductive material.

A container system comprising:

• a seal;
• a container;
• an elastomeric stopper;
• a retainer for retaining the elastomeric stopper, wherein the elastomeric stopper is confined between a rim of the container and the retainer to seal the container;
• a force sensitive resistor between the elastomeric stopper and the rim of the container or the retainer;
• and
• a cap comprising at least a portion of a detection system for detecting a resistance of the force sensitive resistor.