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US 11,981,933 B2Granted
Alignment of cells in engineered tissues
AssigneeRegents of the University of Minnesota
InventorsCaleb Darwin Vogt, Angela Panoskaltsis-Mortari
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Abstract
Devices, systems, and techniques are described for printing pre-aligned microtissues into larger tissue constructs. For example, a method of printing a tissue construct includes aligning cells in a first direction to create pre-aligned microtissues, suspending the pre-aligned microtissues in a liquid to create a bioink, and depositing the pre-aligned microtissues in a second direction to create the tissue construct.
Claims13
A method of printing a tissue construct, the method comprising:
- aligning cells in a single direction to create pre-aligned microtissues with the cells aligned in the single direction;
- suspending the pre-aligned microtissues in a liquid to create a bioink comprising the pre-aligned microtissues;
- and
- dispensing the bioink out of a nozzle such that the pre-aligned microtissues exit the nozzle in a flow direction parallel with the single direction of cell alignment to create the tissue construct.
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Dependencies are inferred from the claim text.