Nicotinamide riboside production in filamentous fungi
AssigneeDyadic International (USA), Inc.
InventorsMark Aaron Emalfarb, Ronen Tchelet, Kari Tapio Koivuranta, Marja Hannele Ilmén, Sandra Castillo, Paula Jouhten
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Abstract
The present invention relates to genetically modified ascomycetous filamentous fungi, particularly of the species Thermothelomyces heterothallica, capable of producing elevated amounts of nicotinamide riboside.
Claims14
A genetically modified ascomycetous filamentous fungus for producing nicotinamide riboside or a precursor thereof, the genetically modified filamentous fungus comprising at least one cell comprising three exogenous polynucleotides encoding for SDT1, BNA6, and NMA1, said fungus cell having deleted or disrupted NRK1, NRT1 and PNP1 genes.
Dependencies are inferred from the claim text.