Therapeutic hydrogels and contact lens for corneal melting
AssigneesThe Regents of the University of Colorado, a body corporate, University of New Hampshire
InventorsJung-Jae Lee, Kyung Jae Jeong
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Abstract
The present invention relates to the unexpected discovery of a cross-linked polymer of 2-hydroxyethyl methacrylate and dipicolylamine-containing monomers that can be used as a therapeutic lens to treat ocular diseases or disorders associated with matrix metalloproteinase (MMP) over-activity and/or over-expression, such as but not limited to corneal melting (or keratolysis).
Claims17
A polymer comprising 2-hydroxyethyl methacrylate (HEMA) monomers and at least one dipicolylamine (DPA)-containing methacrylate monomer, wherein the HEMA monomers are at least partially cross-linked.
Dependencies are inferred from the claim text.