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US 11,981,746 B2Granted
MUC16 specific chimeric antigen receptors and uses thereof
AssigneePrecigen, Inc.
InventorsHelen Sabzevari, Rutul Shah
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Abstract
Provided herein are chimeric antigen receptors (CARs) for cancer therapy, and more particularly, CARs containing a scFv from an anti-MUC16 monoclonal antibody. Provided are immune effector cells containing such CARs, and methods of treating proliferative disorders.
Claims81
A nucleic acid encoding a chimeric antigen receptor, wherein the chimeric antigen receptor comprises:
- (a) an antigen-binding domain comprising:
- (i) the amino acid sequence of SEQ ID NO:
- 5;
- and (ii) the amino acid sequence of SEQ ID NO:
- 6;
- (b) a transmembrane domain;
- and
- (c) a cytoplasmic domain.
5 more elements
An immune effector cell comprising a chimeric antigen receptor comprising:
- (a) an antigen-binding domain comprising:
- (i) the amino acid sequence of SEQ ID NO:
- 5;
- and (ii) the amino acid sequence of SEQ ID NO:
- 6;
- (b) a transmembrane domain;
- and
- (c) a cytoplasmic domain.
5 more elements
Dependencies are inferred from the claim text.