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US 11,981,723 B2Granted
Method of targeting exosomes
AssigneeGladiator Biosciences, Inc.
InventorsTerry Hermiston, Maxine Bauzon, Christopher H. Contag, Jonathan Hardy, Masamitsu Kanada
Life of this patent
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Abstract
A method of targeting extracellular vesicles employing a molecule comprising a GLA domain and extracellular vesicles obtained or obtainable from a method are described herein.
Claims26
A method for targeting extracellular vesicles with surface exposed phosphatidyl serine, said method comprising:
- contacting a molecule comprising a gamma-carboxyglutamic acid component (GLA-component), said GLA-component comprises a GLA domain or an active fragment thereof, into a fluid that comprises the extracellular vesicle, and wherein the molecule does not comprise an active catalytic domain from a GLA protein;
- wherein the GLA domain or active fragment thereof is selected from the group consisting of thrombin, factor IX, factor X, protein C, protein S, protein Z, Osteocalcin, Matrix GLA protein, GAS6, Transthretin, Periostin, Proline rich GLA 1, Proline rich GLA 2, Proline rich GLA 3 and Proline rich GLA 4.
Dependencies are inferred from the claim text.