Polynucleotide constructs
AssigneeSirius Therapeutics, Inc.
InventorsSukumar Sakamuri, Curt W. Bradshaw, Laxman Eltepu, Bryan R. Meade, Son Lam
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Abstract
Disclosed are polynucleotide constructs having a strand linked to a moiety carrying one or more auxiliary moieties. Also disclosed are polynucleotide constructs interrupted with a sugar analogue, and polynucleotide constructs with stereochemical{circumflex over ( )} enriched phosphorothioates. The polynucleotide constructs may be provided as hybridized polynucleotide constructs. Also featured are methods of delivery a polynucleotide construct to a cell and methods of reducing the expression of a protein in a cell by contacting the cell with the disclosed polynucleotide construct or hybridized polynucleotide construct.
Claims13
A polynucleotide construct or a salt thereof, comprising a linker conjugated to a polynucleotide and to a plurality of targeting moieties, wherein prior to conjugation of the targeting moieties, the linker has the structure X2,
- and wherein conjugation of the targeting moieties to the linker occurs through one or more of the alkyne moieties of X2, and
- wherein each of the targeting moieties comprises an N-acetyl galactosamine (GalNAc).
Dependencies are inferred from the claim text.