Compositions for treating neurodegenerative diseases
AssigneeCognition Therapeutics, Inc.
InventorsGilbert M. Rishton, Gary C. Look, Susan M. Catalano
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Abstract
The present disclosure relates to novel compounds of Formula I wherein each of Ra, Rb, Rd and Re is independently H; Rc is selected from the group consisting of H, hydroxyl, halo, alkyl, alkoxy, CF3, SO2CH3, and morpholino, R1 is selected from the group consisting of hydrogen, alkyl, phenyl, or —CH═C(CH3)2; and R2 is specific substituted cyclic amino groups. The invention also discloses pharmaceutical compositions containing the compounds and methods of using the compounds and pharmaceutical compositions for treating neurogenerative diseases, including Alzheimer's disease and cognitive decline.
Claims8
A compound of Formula I or pharmaceutically acceptable salt thereof:
- wherein:
- each of Ra, Rb, Rd and Re is independently H;
- Rc is selected from the group consisting of H, hydroxyl, halo, alkyl, alkoxy, CF3, SO2CH3, and morpholino;
- R1 is selected from the group consisting of hydrogen, alkyl, phenyl, or —CH═C(CH3)2;
- and
- R2 is a substituted cyclic amino group, which is:
- (a) selected from the group consisting of:
- wherein R3a is selected from the group consisting of hydrogen and C1-C8 alkyl;
- and n is an integer selected from 0, 1 and 2;
- or
- (b) selected from the group consisting of:
- wherein R9 is independently selected from the group consisting of hydrogen, hydroxyl, sulfonyl, optionally substituted C1-C10 alkyl, optionally substituted C5-C10 aryl, optionally substituted C5-C10 heteroaryl, optionally substituted C3-C10 cycloalkyl and optionally substituted C3-C10 heterocycloalkyl.
Dependencies are inferred from the claim text.