Compound embodiments for hydrogen sulfide production and methods of making and using the same

A method for producing H2S from a COS- or CS2-releasing compound, the method comprising;

• exposing a sample or a subject to the COS- or CS2-releasing compound, which has a structure according to Formula 1, or a pharmaceutical composition thereof;
• and
• (i) measuring a detectable signal that is produced after the sample or the subject has been exposed to the COS- or CS2-releasing compound using UV-visible spectroscopy, fluorescence spectroscopy, phosphorescence spectroscopy, or a combination thereof, wherein the detectable signal indicates that COS or CS2 has been released from the COS- or CS2-releasing compound, and wherein the COS or CS2 provides the H2S;
• and/or
• (ii) measuring a concentration of H2S produced from the COS- or CS2-releasing compound using a methylene blue assay;
• wherein Formula 1 is
• wherein
• X is oxygen, sulfur, NR′ or N+(R′)2, wherein each R′ independently is hydrogen, aliphatic, haloaliphatic, haloheteroaliphatic, heteroaliphatic, aromatic, or any combination thereof;
• W is oxygen or sulfur;
• when Y is oxygen then W is sulfur;
• or when Y is sulfur then W is oxygen or sulfur;
• V is a heteroatom;
• R1, if present, is hydrogen, aliphatic, haloaliphatic, haloheteroaliphatic, heteroaliphatic, aromatic, or any combination thereof;
• R2 is aliphatic, aromatic, heteroaliphatic, or R1 and R2 when taken together with V is a heteroaliphatic group, or
• R2 and R1 together with V form a 4-, 5-, 6-, or 7-membered heterocyclic group;
• R3 is hydrogen, halogen, aliphatic, haloaliphatic, haloheteroaliphatic, heteroaliphatic, aromatic, or any combination thereof;
• R4 is hydrogen, halogen, aliphatic, haloaliphatic, haloheteroaliphatic, heteroaliphatic, aromatic, or any combination thereof;
• and
• each of R6 and R7 independently is hydrogen, aliphatic, haloaliphatic, haloheteroaliphatic, heteroaliphatic, aromatic, or any combination thereof.