Bacteriophage-derived nanopore sensors
AssigneeOhio State Innovation Foundation
InventorsPeixuan Guo, Zhouxiang Ji, Lakmal Jayasinghe, Michael Jordan
Life of this patent
Estimating the term…
Abstract
Disclosed herein are compositions and methods that involve inserting connector protein channels of bacteriophage DNA packaging motors into copolymeric membranes via liposome-polymer fusion, which can be used as nanopore sensors for biomedical applications such as high throughput protein sequencing or cancer diagnosis. For example, disclosed are compositions comprising a copolymeric membrane into which a connector protein channel of a bacteriophage packaging motor has been inserted.
Claims16
A copolymeric membrane comprising a nanopore inserted therein, wherein the nanopore is derived from a connector protein of a bacteriophage DNA packaging motor, wherein the nanopore comprises the aperture forming region of a connector protein of a bacteriophage DNA packaging motor, and wherein the aperture forming region is modified to alter one or more property of the channel of the nanopore.
Dependencies are inferred from the claim text.