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US 11,980,698 B2Granted
Muscle cell patches and uses therefor
AssigneesArizona Board of Regents on Behalf of the University of Arizona, The United States Government as represented by the Department of Veterans Affairs
InventorsJordan J. Lancaster, Steven Goldman
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Abstract
Disclosed herein are contractile cell constructs, methods for using them to treat disease, and methods for making them.
Claims4
A composition comprising a construct comprising contractile cells, or progenitors thereof, adhered to a scaffold,
- wherein the contractile cells are adhered to a surface of a three dimensional fibroblast containing scaffold (3DFCS),
- wherein the contractile cells are present on the surface of the 3DFCS in a ratio of between about 1:15 and about 6:1 with fibroblasts on the 3DFCS,
- wherein the construct is capable of synchronized contractions,
- wherein the contractile cells or progenitor cells thereof are selected from smooth muscle cells, skeletal muscle cells, and cardiac muscle cells, or combinations thereof,
- wherein the contractile cells or progenitor cells thereof were differentiated from pluripotent stem cells.
2 more elements
Dependencies are inferred from the claim text.