Methods and compositions for treating musculoskeletal diseases, treating inflammation, and managing symptoms of menopause
AssigneeSolarea Bio, Inc.
InventorsEric Michael Schott, Gerardo V. Toledo, Maria Juliana Soto-Giron
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Abstract
Described herein are methods and compositions for using microbial agents (probiotics) and agents that promote growth of certain microbes (prebiotics) for management (including prevention and treatment) of musculoskeletal disorders, including osteoporosis, osteopenia, Paget's disease, stunting, osteoarthritis, osteomyelitis, and delayed or non-union fractures. Also described herein are methods and compositions for using probiotics and prebiotics for management of inflammation, and symptoms of menopause.
Claims26
A dietary supplement comprising a combination of four heterologous microbes consisting of Lactobacillus brevis, Lactobacillus plantarum, Leuconostoc mesenteroides, and Pichia kudriavzevii, wherein the combination of four heterologous microbes comprises at least 1×10{circumflex over ( )}7 of each of the four heterologous microbes, wherein each of the four heterologous microbes comprises a gene or gene pathway directed to biosynthesis of short chain fatty acid (SCFA) or metabolites thereof and wherein the combination produces an increased amount of SCFA when grown together relative to the summed amount of SCFA produced by an equivalent amount of each distinct microbe grown in isolation under the same conditions, wherein the combination lessens a decrease in, maintains, or improves bone health in a subject, and wherein the dietary supplement is formulated for oral delivery.
A dietary supplement comprising a combination of four heterologous microbes consisting of Lactobacillus brevis, Lactobacillus plantarum, Leuconostoc mesenteroides, and Pichia kudriavzevii, wherein the combination of four heterologous microbes comprises at least 1×10{circumflex over ( )}7 of each of the four heterologous microbes, wherein each of the four heterologous microbes comprises a gene or gene pathway directed to biosynthesis of short chain fatty acid (SCFA) or metabolites thereof and wherein the combination produces an increased amount of SCFA when grown together relative to the summed amount of SCFA produced by an equivalent amount of each distinct microbe grown in isolation under the same conditions, wherein the combination improves one or more symptoms of menopause in a subject, and wherein the dietary supplement is formulated for oral delivery.
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