Back to results
US 11,980,602 B2Granted
Cannabinoid prodrug compounds
AssigneeFirstlight Pharmaceuticals LLC
InventorKieran John
Life of this patent
Estimating the term…
Abstract
A prodrug compound of cannabidiol (CBD), pharmaceutical composition thereof and methods of use thereof in patients in need.
Claims27
A compound represented by Formula I,
- wherein:
- X is
- wherein:
- R1 is selected from the group consisting of H, C1-10 alkyl, C1-4 alkyl-aryl, C1-4 alkyl-heteroaryl;
- R2 is H or C1-10 alkyl optionally substituted with OH, SH, SC1-4 alkyl, heteroaryl, CONH2, COOH, NH2, NHC(NH)NH2, or aryl, wherein the heteroaryl and aryl is optionally substituted with CN, halogen, CF3, C1-4 alkyl or OH;
- and R3 is selected from the group consisting of C1-10 alkyl, C1-4 alkyl-aryl, C1-4 alkyl-heteroaryl, and
- wherein
- Ra in each instance is OH, or OC1-10alkyl, provided that Ra is a covalent bond when Ra is in a non-terminal position;
- Rb in each instance is independently H or C1-10 alkyl optionally substituted with OH, SH, SC1-4 alkyl, heteroaryl, CONH2, COOH, NH2, NHC(NH)NH2, or aryl, wherein the heteroaryl and aryl is optionally substituted with CN, halogen, CF3, C1-4 alkyl or OH;
- Rc in each instance is independently selected from the group consisting of H, C1-10 alkyl, C1-4 alkyl-aryl, C1-4 alkyl-heteroaryl, wherein Rb and Rc optionally link up to form a 5 to 7 membered ring;
- and m is an integer ranging from 1 to 9.
8 more elements
A pharmaceutical composition comprising a therapeutically effective amount of a compound represented by Formula I,
- wherein:
- X is
- wherein:
- R1 is selected from the group consisting of H, C1-10 alkyl, C1-4 alkyl-aryl, C1-4 alkyl-heteroaryl;
- R2 is H or C1-10 alkyl optionally substituted with OH, SH, SC1-4 alkyl, heteroaryl, CONH2, COOH, NH2, NHC(NH)NH2, or aryl, wherein the heteroaryl and aryl is optionally substituted with CN, halogen, CF3, C1-4 alkyl or OH;
- and R3 is
- wherein
- Ra in each instance is OH, NHC1-10alkyl or OC1-10alkyl, provided that Ra is a covalent bond when Ra is in a non-terminal position;
- Rb in each instance is independently H or C1-10 alkyl optionally substituted with OH, SH, SC1-4 alkyl, heteroaryl, CONH2, COOH, NH2, NHC(NH)NH2, or aryl, wherein the heteroaryl and aryl is optionally substituted with CN, halogen, CF3, C1-4 alkyl or OH;
- Rc in each instance is independently selected from the group consisting of H, C1-10 alkyl, C1-4 alkyl-aryl, C1-4 alkyl-heteroaryl, wherein Rb and Rc optionally link up to form a 5 to 7 membered ring;
- and m is an integer ranging from 1 to 9.
8 more elements
Dependencies are inferred from the claim text.