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AssigneePlas-Free Ltd
InventorsAbd Alrauf Hijazi, Zeev Dvashi
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The presently disclosed subject-matter provides specific compositions, conjugates, device, kits and systems for depleting fibrinolytic agents from biological fluids. The presently disclosed subject-matter further relates to the resulting biological fluid products that are devoid in fibrinolytic activity, therapeutic methods and uses thereof. The conjugates comprise a particle, at least one linker and at least one amino acid, derivative thereof or analog thereof being at least one of 4-(aminomethyl)-cyclo-hexane-carboxylic acid (tranexamic acid), epsilon-amino caproic acid, lysine, cyclohexanecarboxylic acid and 4-methyl-cyclohexanecarboxylic acid. A plurality of different conjugates (e.g. differing in particle size or type of linker) can be used.
A plurality of conjugates or a composition comprising said plurality of conjugates, wherein each conjugate comprises a particle, at least one linker and at least one amino acid, derivative thereof or analog thereof, wherein the plurality of conjugates comprises at least two different conjugates, and wherein said amino acid, derivative thereof or analog thereof is 4-(aminomethyl)-cyclo-hexane-carboxylic acid (tranexamic acid), and wherein at least one conjugate in said plurality of conjugates is at least one of:
A conjugate comprising a particle, at least one linker and at least one amino acid, derivative thereof or analog thereof, said conjugate being any one of:
Dependencies are inferred from the claim text.