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US 11,975,032 B2Granted
Medicament for liver regeneration and for treatment of liver failure
AssigneeMedizinische Hochschule Hannover
InventorsLars Zender, Torsten Wuestefeld
Life of this patent
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Abstract
The present invention relates to the use of a compound which inhibits the activity of MKK4 as a medicament for the treatment of a patient suffering from an impaired liver function, to the use of a compound as a medicament for the treatment of liver failure, including acute/fulminant or chronic liver failure and/or for increasing the regeneration of liver tissue in a patient.
Claims8
A method of medical treatment, the method comprising:
- administering to a patient in need of treatment for liver failure and/or hepatocyte apoptosis, an oligonucleotide which hybridizes to an mRNA, said mRNA having the sequence of SEQ ID NO:
- 1204 under physiological conditions and inhibits mitogen-activated protein kinase kinase 4 (MKK4), and wherein the oligonucleotide is administered to the patient in an amount that regenerates the patient's hepatocytes and/or protects the patient's hepatocytes from apoptosis.
Dependencies are inferred from the claim text.