T regulatory (Treg) cell transplantation in osteogenesis imperfecta (OI)
AssigneeMUSC Foundation for Research Development
InventorsMeenal Mehrotra, In-Hong Kang, Uday Baliga
Life of this patent
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Abstract
The present invention relates to compositions comprising induced T regulatory cells (iTregs), methods of making the compositions, and methods of using the compositions for enhancing bone remodeling in the treatment of Osteogenesis Imperfecta (OI).
Claims17
A composition for enhancing bone remodeling, or for treating osteogenesis imperfecta (OI), comprising at least one bone marrow (BM) cell, and at least one selected from the group consisting of:
- an induced T regulatory cell (iTreg), and iTreg conditioned medium (CM).
A method for enhancing bone remodeling, or for treating a skeletal disease or disorder, comprising administering to a subject having a skeletal disease or disorder a composition comprising at least one selected from the group consisting of:
- an induced T regulatory cell (iTreg), and iTreg conditioned medium (CM).
A composition for inducing the formation of iTregs, comprising anti-CD3 antibody present at a concentration of 5 μg/mL, anti-CD28 antibody present at a concentration of 5 μg/mL, IL-2 present at a concentration of 100U/mL, TGF-β present at a concentration of 5 ng/mL, and retinoic acid at a concentration of 40 nmol/mL.
Dependencies are inferred from the claim text.