Sulfated glycosaminoglycan biomaterials as proteoglycan mimics
AssigneeGlycologix, Inc.
InventorThomas H. Jozefiak
Life of this patent
Estimating the term…
Abstract
Polymer conjugates are provided that are capable of mimicking functions of natural proteoglycans found in the extracellular matrix of connective tissues. The polymer conjugates of the invention have utility in treating a subject suffering soft tissue conditions. Also provided are simple and scalable chemical processes for the preparation of the polymer conjugates of the invention.
Claims13
A water-soluble branched polymer conjugate comprising a plurality of sulfated glycosaminoglycan (GAG) polymer chains, wherein each sulfated GAG polymer chain is linked to one or more sulfated GAG polymer chains via a linker derived from divinylsulfone, and wherein the polymer conjugate is soluble in aqueous solution and has a molecular weight that is 3× to 100× that of an individual, nonlinked sulfated GAG.
Dependencies are inferred from the claim text.