Bismuth-thiol compositions and methods for treating wounds

A method of treating, managing, or preventing a bacterial infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a liposome-free composition comprising a suspension of microparticles comprising a bismuth-thiol (BT) compound selected from the group consisting of BisBAL, BisEDT, Bis-dimercaprol, BisDTT, Bis-2-mercaptoethanol, Bis-DTE, Bis-Pyr, Bis-Ery, Bis-Tol, Bis-BDT, Bis-PDT, Bis-Pyr/Bal, Bis-Pyr/BDT, BisPyr/EDT, Bis-Pyr/PDT, Bis-Pyr/Tol, Bis-Pyr/Ery, bismuth-1-mercapto-2-propanol, and Bis-EDT/2-hydroxy-1-propanethiol, wherein the microparticles have a D90 of less than 2 μm, a D50 of less than or equal to 0.72 μm to 1.3 μm, and/or a D10 of less than or equal to 0.33 μm to 0.70 μm.