Cyclic capillary electrophoresis device
AssigneesImec Vzw, Katholieke Universiteit Leuven
InventorsKoen Martens, Chengxun Liu, Camila Dalben Madeira Campos, Rita Vos
Life of this patent
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Abstract
A cyclic capillary electrophoresis device includes a capillary channel that forms a closed loop. The capillary channel comprises an inner half facing toward a space enclosed by the loop, where the inner half having an inner wall of first charge density, and an outer half facing away from the space enclosed by the loop, where the outer half having an inner wall surface of second charge density. A difference between the first and the second charge densities exists or can be turned on. The difference is configured to create a smaller average electroosmotic flow velocity in the inner half than in the outer half.
Claims20
A cyclic capillary electrophoresis device comprising:
- a capillary channel, wherein the capillary channel forms a closed loop, and wherein the capillary channel includes:
- an inner half formed into a substrate and including a vertical inner wall surface defining an inner perimeter of the closed loop wherein the vertical inner wall surface is charged to a first charge density;
- and
- an outer half formed into the substrate opposite to the inner half and including a vertical inner wall surface defining an outer perimeter of the closed loop wherein the vertical inner wall surface is charged to a second charge density, wherein the vertical inner wall surface of the inner perimeter and the vertical inner wall surface of the outer perimeter are formed parallel to each other, and are enclosed by a cover arranged to close the closed loop formed into the substrate,
- a charge density difference generated between the first charge density maintained at the vertical inner wall surface of the inner half and the second charge density maintained at the vertical inner wall surface of the outer half, and
- a first electroosmotic flow velocity generated in response to the charge density difference adjacent to the inner wall surface of the inner half and a second electroosmotic flow velocity generated in response to the charge density difference adjacent to the inner wall surface of the outer half and wherein the difference between the first and second electroosmotic flow velocities occurs between the inner half and the outer half along a plane traverse to a fluid flow within the closed loop defined between the inner perimeter and the outer perimeter.
Dependencies are inferred from the claim text.