Methods for treating hypertension using an anti-BMP10 monoclonal antibody or fragment thereof

A method for treating hypertension, a renal glomerular disorder, a renal tubulointerstitial disorder, and/or heart diastolic dysfunction in a subject, comprising administering a therapeutically-effective amount of an antagonist for at least one of BMP10 and a BMP9/BMP10 heterodimer to a subject in need thereof,

• wherein the antagonist for at least one of BMP10 and a BMP9/BMP10 heterodimer is a monoclonal antibody or an antibody fragment thereof which binds to BMP10,
• wherein the monoclonal antibody and the antibody fragment thereof comprises:
• a heavy chain comprising heavy chain complementarity determining regions (CDRs) 1 to 3,
• wherein heavy chain CDR 1 comprises the amino acid sequence of SEQ ID NO:
• 29,
• wherein heavy chain CDR 2 comprises the amino acid sequence of SEQ ID NO:
• 30 or an amino acid sequence in which serine at position 16 of the amino acid sequence of SEQ ID NO:
• 30 is substituted with aspartic acid, and
• wherein heavy chain CDR3 comprises the amino acid sequence of SEQ ID NO:
• 31;
• a light chain comprising light chain CDRs 1 to 3, wherein light chain CDRs 1 to 3 comprise the amino acid sequences of SEQ ID NO:
• 32 to 34, respectively;
• and
• wherein the renal glomerular disorder, the renal tubulointerstitial disorder and heart diastolic dysfunction are caused by high blood pressure.