Application of skeletal muscle secreted factor THBS4 in preparation of drug for improving systemic glucose and lipid metabolism
AssigneeInstitute of Microbiology, Guangdong Academy of Sciences (Guangdong Detection Center of Microbiology
InventorLiwei Xie
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Abstract
An application of a skeletal muscle secreted factor Thbs4 in a preparation of a drug for improving systemic glucose and lipid metabolism is provided. According to the present invention, it is found through experiments that Thbs4 increases a body's metabolic rate by activating a beige-like change of white adipose, relieves the metabolic disorder caused by high-fat diet, and reveals its application value in the treatment of the metabolic disorder.
Claims8
A method of improving systemic glucose and lipid metabolism in a subject comprising a step of intramuscular injection in the subject of an expression vector that expresses a recombinant skeletal muscle secreted factor Thbs4 protein in the subject, wherein the recombinant skeletal muscle secreted factor Thbs4 protein has the amino acid sequence shown in SEQ ID NO:
- 1.
A drug for improving a systemic glucolipid metabolism in a subject, comprising an expression vector comprising a gene for expression of recombinant skeletal muscle secreted factor Thbs4 protein, wherein the recombinant skeletal muscle secreted factor Thbs4 protein has the amino acid sequence shown in SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.