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US 11,969,428 B2Granted
Methods and pharmaceutical compositions for treating lymphoid malignancy
AssigneeThomas Diacovo
InventorThomas Diacovo
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AssigneeThomas Diacovo
InventorThomas Diacovo
Estimating the term…
The present invention provides, inter alia, methods for treating, preventing, or ameliorating the effects of a lymphoid malignancy, such as those associated with a mutated phosphatase and tensin homolog (PTEN) gene, or T-cell acute lymphoblastic leukemia (T-ALL). These methods include administering to a subject an effective amount of a phosphoinositide 3-kinase-delta (PI3Kδ) inhibitor and a phosphoinositide 3-kinase-gamma (PI3Kγ) inhibitor. The present invention also provides pharmaceutical compositions for treating the effects of a lymphoid malignancy. This invention further provides a method for identifying a subject who may benefit from co-treatment with a PI3Kδ inhibitor and a PI3Kγ inhibitor. This method includes determining from a sample of the subject whether the subject has a mutated PTEN gene. Additionally, this invention provides methods for identifying a compound that has both PI3Kδ and PI3Kγ inhibitory activity.
A method for treating or ameliorating the effects of a lymphoid malignancy comprising administering to a subject in need thereof an effective amount of a small molecule to selectively inhibit phosphoinositide 3-kinase-delta (PI3Kd) and phosphoinositide 3-kinase-gamma (PI3Kg) isoforms, wherein the small molecule to selectively inhibit PI3Kd and PI3Kg isoforms is CAL-130, wherein the lymphoid malignancy is T-cell acute lymphoblastic leukemia (T-ALL) or T-cell acute lymphoblastic lymphoma, and wherein the CAL-130 has the chemical structure of:
A method for treating or ameliorating the effects of a lymphoid malignancy associated with a mutated phosphatase and tensin homolog (PTEN) gene in a subject comprising administering to the subject an effective amount of a small molecule to selectively inhibit phosphoinositide 3-kinase-delta (PI3Kd) and phosphoinositide 3-kinase- gamma (PI3Kg) isoforms, wherein the small molecule to selectively inhibit PI3Kd and PI3Kg isoforms is CAL-130, wherein the lymphoid malignancy is T-cell acute lymphoblastic leukemia (T-ALL) or T-cell acute lymphoblastic lymphoma, and wherein the CAL-130 has the chemical structure of:
A pharmaceutical composition for treating the effects of a lymphoid malignancy comprising a therapeutically effective amount of CAL-130 and pharmaceutically acceptable carrier thereof, wherein the lymphoid malignancy is T-cell acute lymphoblastic leukemia (T-ALL) or T-cell acute lymphoblastic lymphoma, and wherein the CAL-130 has the chemical structure of:
A method for treating or ameliorating the effects of a malady comprising T-cell acute lymphoblastic leukemia (T-ALL) or T-cell acute lymphoblastic lymphoma, said method comprising administering to a subject in need thereof a therapeutically effective amount of CAL-130, wherein the CAL-130 has the chemical structure of:
Dependencies are inferred from the claim text.