Method for calibrating a device for measuring the concentration of creatinine
AssigneeRadiometer Medical ApS
InventorThomas Kjaer
Life of this patent
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Abstract
A method of calibrating a device for measuring the concentration of creatinine using one or more calibration solutions, the method comprising: receiving concentrations at an initial time of creatine, Cr, and/or creatinine, Crn, of the one or more calibration solutions; receiving outputs of the measuring device at the end time; calculating the concentration of Cr and/or Crn in the calibration solutions at an end time using a temperature model, wherein the temperature model indicates changes in temperature of the calibration solutions from the initial time to the end time; and determining a relationship between the outputs of the measuring device and the calculated concentrations of Cr and/or Crn.
Claims13
A method for recalibrating a measuring device for measuring a concentration of creatinine in a solution using one or more calibration solutions, the method comprising:
- providing the measuring device for determining the concentration of creatinine in the solution, wherein the measuring device comprises a sensor having a sensitivity in need of recalibration;
- providing the one or more calibration solutions comprising a creatine (Cr) calibration solution and/or a creatinine (Crn) calibration solution for the sensor;
- receiving concentrations at an initial time of Cr and/or Crn in the one or more calibration solutions;
- receiving outputs of the measuring device at an end time;
- calculating the concentration of Cr and/or Crn in the one or more calibration solutions at the end time using a two-temperature temperature model, rate equations for an equilibrium reaction of Cr and Crn, and the Arrhenius equation,
- wherein the two-temperature temperature model is determined by receiving measurements of one or more changes in temperature of the one or more calibration solutions from one or more temperature probes from the initial time to the end time;
- determining the sensitivity of the sensor based on a relationship between the outputs of the measuring device and the calculated concentration of Cr and/or Crn, and
- recalibrating the sensitivity of the sensor for subsequent determination of the concentration of Cr and/or Crn in a sample.
Dependencies are inferred from the claim text.