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AssigneeChugai Seiyaku Kabushiki Kaisha
InventorsYoshiaki Isshiki, Fumio Watanabe, Masaki Tomizawa, Kihito Hada, Kazuo Hattori, Kenichi Kawasaki, Ikumi Hyodo, Toshihiro Aoki
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The present disclosure provides, for example, a compound represented by the general formula below or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of the compound or salt: wherein X1, X2, X3 and X4 are each independently —CR2═ or N═, R2 is, for example, a halogen atom, R1 is, for example, —S(═O)2—NH—R8, R8 is, for example, a C1-6 alkyl group, R3 is, for example, a hydrogen atom, R5 is, for example, a halogen atom, R6 is, for example, a hydrogen atom, and R4 is, for example, a cyclopropyl group. The compounds, salts or solvates provided by the present disclosure exhibit high RAF/MEK complex-stabilizing activity and can be used for the treatment or prevention of cell proliferative disorders, particularly cancers.
A compound represented by general formula (6) below or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of said compound or salt:
A compound or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of said compound or salt, said compound being selected from the group consisting of:
Dependencies are inferred from the claim text.