US 11,964,938 B2 · 3-phenyl-4-hexynoic acid derivatives as GPR40 agonists

Abstract

A compound of the formula (I) wherein R represents a straight or branched, primary or secondary acyclic hydrocarbyl C3-C15 group, which can be saturated or unsaturated, or a straight or branched, primary or secondary acyclic hydrocarbyl C3-C15 group, which can be saturated or unsaturated and wherein one or more of hydrogen atoms is replaced with fluorine atom; X represents hydrogen atom or halogen atom, and * denotes chiral center, and salts thereof. The compound is useful for the treatment of diseases mediated by GPR40, in particular type II diabetes. (I)

Claims23

Dependent claims

A compound of formula (I)

wherein:
R represents:
a straight or branched, primary or secondary acyclic hydrocarbyl C3-15 group, which can be saturated or unsaturated, or
a straight or branched, primary or secondary acyclic hydrocarbyl C3-15 group, which can be saturated or unsaturated and wherein one or more hydrogen is replaced with a fluorine;
X represents a hydrogen or a halogen, and
* denotes a chiral center,
or a salt thereof,
with the proviso that formula (I) excludes:
3-(4-([2E,3Z])-2-propylidenepent-3-en-1-yl]oxy)phenyl)hex-4-ynoic acid and (3R/S)-3-[4-(prop-2-yn-1-yloxy)phenyl]hex-4-ynoic acid.

6 more elements

Dependencies are inferred from the claim text.

Facts

Application

16/960,700Filed 7 Jan 2019

Priority

PL 4242278 Jan 2018

Published

US 2020/0399198 A124 Dec 2020

Granted

23 Apr 2024

Term ends

Not estimatedThe source records don’t support an estimate.

Classification9 codes

C07C 59/68
The non-carboxylic part of the ether containing six-membered aromatic rings: the oxygen atom of the ether group being bound to a non-condensed…
A61P 3/10
For glucose homeostasis: for hyperglycaemia, e.g. antidiabetics
C07C 57/42
Containing six-membered aromatic rings: having unsaturation outside the rings
C07C 57/60
Containing six-membered aromatic rings: having unsaturation outside the rings

3-phenyl-4-hexynoic acid derivatives as GPR40 agonists

Life of this patent

3-phenyl-4-hexynoic acid derivatives as GPR40 agonists

Life of this patent

Abstract

Claims23