Systems and method for detecting cognitive impairment

A system for determining cognitive impairment (CI) comprising:

• a database including a quantification of retinal structure and retinal function of a plurality of eyes associated with a plurality of patients, the quantification providing a baseline cognitive impairment (CI) reference;
• and
• at least one processor configured to
• receive an electroretinogram (ERG) of a retina of a patient,
• determine a measure of functionality of neurons in the retina based on the ERG,
• receive a retinal image of the retina,
• skeletonize the retinal image as a skeletonized retinal image,
• determine a structural measure of the first retina based on
• a generalized dimension spectrum and singularity spectrum of the skeletonized retinal image, and
• a lacunarity parameter of the skeletonized retinal image,
• compare the measure of functionality and the structural measure of the retina to the database, and
• determine a level of cognitive impairment of the patient based on the comparing.

A non-transitory computer-readable medium storing instructions that when executed by one or more processors, cause the one or more processors to:

• form a database including a quantification of retinal structure and retinal function of a plurality of eyes associated with a plurality of patients, the quantification providing a baseline cognitive impairment (CI) reference;
• receive an electroretinogram (ERG) of a retina of a patient;
• determine a measure of functionality of neurons in the retina based on the ERG;
• receiving a retinal image of the retina;
• skeletonize the retinal image as a skeletonized retinal image;
• determine a structural measure of the first retina based on
• a generalized dimension spectrum and singularity spectrum of the skeletonized retinal image, and
• a lacunarity parameter of the skeletonized retinal image;
• comparing the measure of functionality and the structural measure of the retina to the database;
• and
• determine a level of cognitive impairment of the patient based on the comparing.