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US 11,959,140 B2Granted
Method for monitoring metabolism before and after exercise or injury using salivary micro-RNAs
AssigneesQuadrant Biosciences Inc., The Penn State Research Foundation, The Research Foundation for The State University of New York
InventorsRichard Uhlig, Steven D. Hicks, Frank A. Middleton
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Abstract
A method for evaluating or monitoring metabolic effects of exercise or injury by detecting and/or quantifying microR-NAs in saliva. Compositions and methods of treatment based on detection of microRNAs.
Claims8
A method for selecting an injury recovery exercise regimen for a subject having a concussion or traumatic brain injury (TBI) comprising:
- detecting pre-exercise levels of miR-7154-3p, miR-200b-5p, miR-5582-3p, miR-6859-3p, miR-6751-5p, and miR-4419a in a saliva sample obtained from the subject having the concussion or TBI,
- administering an injury recovery exercise regimen to said subject,
- detecting post-exercise levels of miR-7154-3p, miR-200b-5p, miR-5582-3p, miR-6859-3p, miR-6751-5p, and miR-4419a in a saliva sample obtained from the subject;
- selecting the injury recovery regimen for said subject when the post-exercise levels of miR-7154-3p, miR-200b-5p, miR-5582-3p, miR-6859-3p, miR-6751-5p, and miR-4419a are increased in comparison to the pre-exercise levels of miR-7154-3p, miR-200b-5p, miR-5582-3p, miR-6859-3p, miR-6751-5p, and miR-4419a;
- and
- continuing to administer the selected injury recovery exercise regimen to said subject.
3 more elements
Dependencies are inferred from the claim text.