Delivery method
AssigneesCell Guidance Systems Limited, Yuka Matsuzakt, Hajime Mori
InventorsYuka Matsuzaki, Hajime Mori, Christian Pernstich, Michael Howard Jones
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Abstract
A method of altering cells comprising culturing them in a growth factor gradient, wherein said gradient is provided by a polyhedra delivery system (PODS) that releases the growth factor to set up the gradient.
Claims18
A method of differentiating cells into neurons comprising culturing the cells under static conditions in the presence of a neurotrophic growth factor gradient, wherein the gradient is generated by sustained release of the neurotrophic growth factor by a polyhedra delivery system (PODS) to set up the gradient, the PODS are in the form of microcrystals comprising polyhedrin proteins and the neurotrophic growth factor and the concentration of the neurotrophic growth factor is the highest at the PODS, and decreases with distance away from the PODS, and retains neurotrophic growth factor activity and wherein the culturing under static conditions is maintained through the differentiation process.
Dependencies are inferred from the claim text.