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US 11,958,917 B2Granted
Compositions of hydroxypropyl-beta-cyclodextrin and methods of purifying the same
AssigneeBeren Therapeutics P.B.C.
InventorsSteven Pfeiffer, Dustin McMinn, Gabor Benkovics
Life of this patent
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Abstract
Compositions comprising mixtures of hydroxypropyl-β-cyclodextrin, wherein the compositions may be isomerically purified, and methods of isomerically purifying a mixture of hydroxypropyl-β-cyclodextrins.
Claims33
A composition comprising a mixture of isomerically-purified hydroxypropyl β-cyclodextrin molecules comprising:
- β-cyclodextrin substituted with eight hydroxypropyl groups (“DS-8”);
- β-cyclodextrin substituted with nine hydroxypropyl groups (“DS-9”);
- β-cyclodextrin substituted with ten hydroxypropyl groups (“DS-10”);
- β-cyclodextrin substituted with eleven hydroxypropyl groups (“DS-11”);
- β-cyclodextrin substituted with twelve hydroxypropyl groups (“DS-12”);
- β-cyclodextrin substituted with thirteen hydroxypropyl groups (“DS-13”);
- and
- β-cyclodextrin substituted with fourteen hydroxypropyl groups (“DS-14”),
- wherein the composition comprises less than 1% β-cyclodextrin substituted with seven hydroxypropyl groups (“DS-7”), and wherein the composition comprises no more than 1 ppm propylene oxide.
6 more elements
A composition comprising a mixture of isomerically-purified hydroxypropyl
- β-cyclodextrin molecules comprising:
- β-cyclodextrin substituted with eight hydroxypropyl groups (“DS-8”);
- β-cyclodextrin substituted with nine hydroxypropyl groups (“DS-9”);
- β-cyclodextrin substituted with ten hydroxypropyl groups (“DS-10”);
- β-cyclodextrin substituted with eleven hydroxypropyl groups (“DS-11”);
- β-cyclodextrin substituted with twelve hydroxypropyl groups (“DS-12”);
- β-cyclodextrin substituted with thirteen hydroxypropyl groups (“DS-13”);
- and
- β-cyclodextrin substituted with fourteen hydroxypropyl groups (“DS-14”),
- wherein the composition comprises less than 1% β-cyclodextrin substituted with seven hydroxypropyl groups (“DS-7”), and wherein about 15% to about 21% of the hydroxypropyl substitutions in the hydroxypropyl β-cyclodextrin molecules are located at the 3-O-position.
7 more elements
A composition comprising a mixture of isomerically-purified hydroxypropyl β-cyclodextrin molecules comprising:
- β-cyclodextrin substituted with eight hydroxypropyl groups (“DS-8”);
- β-cyclodextrin substituted with nine hydroxypropyl groups (“DS-9”);
- β-cyclodextrin substituted with ten hydroxypropyl groups (“DS-10”);
- β-cyclodextrin substituted with eleven hydroxypropyl groups (“DS-11”);
- β-cyclodextrin substituted with twelve hydroxypropyl groups (“DS-12”);
- β-cyclodextrin substituted with thirteen hydroxypropyl groups (“DS-13”);
- and
- β-cyclodextrin substituted with fourteen hydroxypropyl groups (“DS-14”),
- wherein the composition comprises less than 1% β-cyclodextrin substituted with seven hydroxypropyl groups (“DS-7”), and wherein about 79% to about 85% of the hydroxypropyl substitutions in the hydroxypropyl β-cyclodextrin molecules are located at the 2-O-position.
6 more elements
Dependencies are inferred from the claim text.