Anti-coagulation factor XI antibody
AssigneeShanghai Benemae Pharmaceutical Corporation
InventorsWenyi Wang, Quan Yu, Xiaowu Liu, John Liuzhong Xu, Zhiqiang Du
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Abstract
Disclosed are antibodies thereof that bind to coagulation factor XI (FXI) and/or its activated form factor XIa (FXIa), or to fragments of FXI and/or FXIa, and compositions containing the antibodies. Also disclosed are methods of preparing the antibodies and use of the antibodies for treating and/or preventing coagulation associated conditions such as thrombosis and complications or conditions associated with thrombosis.
Claims15
An isolated anti-FXI or anti-FXIa antibody that specifically binds to human FXI or FXIa or immunologically active portion thereof wherein the antibody or portion thereof, comprises a combination of CDR selected from the group consisting of combinations a) to l):
- combination a) CDRs of SEQ ID NOs:
- 11-16;
- combination b) CDRs of SEQ ID NOs:
- 27-32;
- combination c) CDRs of SEQ ID NOs:
- 43-48;
- combination d) CDRs of SEQ ID NOs:
- 59-64;
- combination e) CDRs of SEQ ID NOs:
- 75-80;
- combination f) CDRs of SEQ ID NOs:
- 91-96;
- combination g) CDRs of SEQ ID NOs:
- 107-112;
- combination h) CDRs of SEQ ID NOs:
- 123-128;
- combination i) CDRs of SEQ ID NOs:
- 139-144;
- combination j) CDRs of SEQ ID NOs:
- 155-160;
- combination k) CDRs of SEQ ID NOs:
- 171-176;
- and
- combination l) CDRs of SEQ ID NOs:
- 187-192.
An isolated anti-FXI or anti-FXIa antibody that specifically binds to human FXI or FXIa or immunologically active portion thereof, wherein the antibody comprises a pair of sequences selected from the group consisting of SEQ ID NOs:
- 9-10, SEQ ID NOs:
- 25-26, SEQ ID NOs:
- 41-42, SEQ ID NOs:
- 57-58, SEQ ID NOs:
- 73-74, SEQ ID NOs:
- 89-90, SEQ ID NOs:
- 105-106, SEQ ID NOs:
- 121-122, SEQ ID NOs:
- 137-138, SEQ ID NOs:
- 153-154, SEQ ID NOs:
- 169-170, SEQ ID NOs:
- 185-186, SEQ ID NOs;
- 197-198, SEQ ID NOs:
- 199-200, SEQ ID NOs:
- 201-202, SEQ ID NOs:
- 204-205, SEQ ID NOs:
- 206-207, and SEQ ID NOs:
- 208-209.
Dependencies are inferred from the claim text.