Bispecific antigen binding molecules that bind HER2, and methods of use thereof

A bispecific antigen-binding molecule comprising:

• a first antigen-binding domain (D1);
• and
• a second antigen-binding domain (D2);
• wherein D1 specifically binds a first epitope of human HER2;
• and
• wherein D2 specifically binds a second epitope of human HER2;
• and
• wherein D1 comprises three heavy chain complementarity determining regions (HCDR1, HCDR2 and HCDR3) within a heavy chain variable region (HCVR) comprising the amino acid sequence of SEQ ID NO:
• 2 and three light chain complementarity determining regions (LCDR1, LCDR2 and LCDR3) within a light chain variable region (LCVR) comprising the amino acid sequence of SEQ ID NO:
• 18, wherein the HCDR1 comprises the amino acid sequence of SEQ ID NO:
• 4;
• the HCDR2 comprises the amino acid sequence of SEQ ID NO:
• 6;
• the HCDR3 comprises the amino acid sequence of SEQ ID NO:
• 8;
• the LCDR1 comprises the amino acid sequence of SEQ ID NO:
• 20;
• the LCDR2 comprises the amino acid sequence of SEQ ID NO:
• 22;
• and the LCDR3 comprises the amino acid sequence of SEQ ID NO:
• 24;
• and
• wherein D2 comprises three heavy chain complementarity determining regions (HCDR1, HCDR2 and HCDR3) within a heavy chain variable region (HCVR) comprising the amino acid sequence of SEQ ID NO:
• 10 and three light chain complementarity determining regions (LCDR1, LCDR2 and LCDR3) within a light chain variable region (LCVR) comprising the amino acid sequence of SEQ ID NO:
• 18, wherein the HCDR1 comprises the amino acid sequence of SEQ ID NO:
• 12;
• the HCDR2 comprises the amino acid sequence of SEQ ID NO:
• 14;
• the HCDR3 comprises the amino acid sequence of SEQ ID NO:
• 16;
• the LCDR1 comprises the amino acid sequence of SEQ ID NO:
• 20;
• the LCDR2 comprises the amino acid sequence of SEQ ID NO:
• 22;
• and the LCDR3 comprises the amino acid sequence of SEQ ID NO:
• 24.