Anti-age antibodies for treating neurodegenerative disorders

A method of treating a neurodegenerative disorder, comprising killing or inducing apoptosis in senescent glial cells by administering to a patient in need thereof, a composition comprising an advanced glycation end-product (AGE) antibody,

• wherein the AGE antibody is cytotoxic,
• the AGE antibody binds a carboxymethyllysine-modified protein,
• the neurodegenerative disorder is Alzheimer's disease (AD) or Parkinson's disease (PD),
• the AGE antibody comprises
• a heavy chain, and
• a light chain,
• the heavy chain comprises a sequence selected from the group consisting of SEQ ID NO:
• 29, SEQ ID NO:
• 31, and SEQ ID NO:
• 33, and
• the light chain comprises a sequence selected from the group consisting of SEQ ID NO:
• 35, SEQ ID NO:
• 37, and SEQ ID NO:
• 39.