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US 11,958,895 B2Granted
Anti-influenza neuraminidase monoclonal antibodies and uses thereof
AssigneeUniversity of Rochester
InventorsJames J. Kobie, Luis Martinez-Sobrido, Michael Piepenbrink, Aitor Nogales
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Abstract
The present invention relates to broadly neutralizing anti-influenza monoclonal antibodies or antigen-binding fragments thereof. The present invention further relates to therapeutic uses of the isolated antibody or the antigen-binding fragment thereof.
Claims16
An isolated antibody or antigen-binding fragment thereof that specifically binds to a neuraminidase of influenza virus, comprising:
- (i) a heavy chain variable region that comprises HCDR1, HCDR2, and HCDR3 comprising the respective sequences of a HCDR of SEQ ID NOs:
- 27-29, and
- (ii) a light chain variable region that comprises LCDR1, LCDR2 and LCDR3 comprising the respective sequences of a LCDR of SEQ ID NOs:
- 30-32.
1 more element
Dependencies are inferred from the claim text.