Compositions of phosphorylated tau peptides and uses thereof

A liposome, comprising:

• a. a tau peptide comprising the amino acid sequence of SEQ ID NO:
• 2, wherein the tau peptide is presented on the surface of the liposome;
• b. a helper T cell epitope having an amino acid sequence selected from the group consisting of SEQ ID NOs:39, 40, 41, 42, and 43;
• c. a lipidated CpG oligonucleotide having the nucleotide sequence selected from the group consisting of SEQ ID NO:18 to SEQ ID NO:22, wherein the CpG oligonucleotide is covalently linked to at least one cholesterol via a linker;
• and
• d. monophosphoryl lipid A (MPLA).

A liposome, comprising:

• a. a tau peptide comprising the amino acid sequence of SEQ ID NO:
• 28, wherein the tau peptide is presented on the surface of the liposome;
• b. a helper T cell epitope having an amino acid sequence selected from the group consisting of SEQ ID NOs:
• 13, 14 or 15,
• c. a lipidated CpG oligonucleotide having the nucleotide sequence selected from the group consisting of SEQ ID NO:18, wherein the CpG oligonucleotide is covalently linked to at least one cholesterol via a linker;
• and
• d. monophosphoryl lipid A (MPLA).