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US 11,958,886 B2Granted
IL-1RA cDNAs
AssigneeUniversity of Florida Research Foundation, Inc.
InventorSteven C. Ghivizzani
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Abstract
The present disclosure relates to compositions and methods for treatment of degenerative conditions of large weight-bearing joints, such as osteoarthritis, by intra-articular delivery of a codon-modified IL-1Ra encoding gene.
Claims18
A method of treating osteoarthritis in a subject, the method comprising:
- intra-articularly administering a pharmaceutical composition comprising:
- (a) a recombinant adeno-associated virus (rAAV) particle comprising a codon-modified gene encoding interleukin-1 receptor antagonist (IL-1Ra), and
- (b) a pharmaceutically acceptable carrier,
- wherein the codon-modified gene is selected from the group consisting of:
- (i) a codon-modified gene encoding human IL-1Ra and having a nucleotide sequence mismatch of 10-30% compared to the wild-type human IL-1Ra gene as set forth in SEQ ID NO:
- 9;
- and
- (ii) a codon-modified gene encoding equine IL-1Ra and having a nucleotide sequence mismatch of 10-30% compared to the wild-type equine IL-1Ra gene as set forth in SEQ ID NO:
- 1;
- wherein the codon-modified gene increases expression of IL-1Ra compared to a wild-type gene encoding IL-1Ra, and
- wherein the administering is to a joint of the subject to treat osteoarthritis.
8 more elements
Dependencies are inferred from the claim text.