Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof

A compound represented by Formula (IV) or a pharmaceutically acceptable salt thereof:

• wherein:
• Ra is selected from the group consisting of:
• 1) Hydrogen;
• 2) Substituted or unsubstituted —C1-C6 alkoxy;
• 3) Substituted or unsubstituted —C1-C8 alkyl;
• 4) Substituted or unsubstituted —C2-C8 alkenyl;
• 5) Substituted or unsubstituted —C2-C8 alkynyl;
• 6) Substituted or unsubstituted arylalkyl;
• 7) Substituted or unsubstituted aryl;
• and
• 8) Substituted or unsubstituted C3-C6-cycloalkyl;
• Rb is selected from the group consisting of:
• 1) Hydrogen;
• 2) Substituted or unsubstituted —C1-C8 alkyl;
• 3) Substituted or unsubstituted —C2-C8 alkenyl;
• 4) Substituted or unsubstituted —C2-C8 alkynyl;
• 5) Substituted or unsubstituted arylalkyl;
• and
• 6) Substituted or unsubstituted aryl;
• or Ra and Rb are taken together with the nitrogen atom to which they are attached to form a heterocyclic ring;
• and
• m is selected from 0, 1, 2 and 3.