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US 11,958,877 B2Granted
Nucleotide analogues
AssigneeSingular Genomics Systems, Inc.
InventorsRonald Graham, Olga Adelfinskaya, Megha Cila, Rodrigo Rodriguez, Abrehet Abdu, Eli N. Glezer
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Abstract
Disclosed herein, interalia, are compounds, compositions, and methods of using the same for the sequencing of a nucleic acid.
Claims21
A kit comprising a labeled nucleotide, wherein the labeled nucleotide comprises:
- (i) a cleavable moiety covalently bound to the 3′ oxygen of said labeled nucleotide, wherein the cleavable moiety has the formula -L1P-S—S—R6P(I);
- and
- (ii) a nucleobase linked via a covalent linker to a first detectable moiety, wherein said covalent linker comprises
- wherein,
- R102 is unsubstituted C1-C4 alkyl;
- L1P is a substituted methylene, wherein L1P is substituted with a substituted or unsubstituted alkyl, or a substituted or unsubstituted heteroalkyl;
- and
- R6P is unsubstituted methyl or unsubstituted ethyl.
5 more elements
Dependencies are inferred from the claim text.