Methods of using metal complexes to promote wound healing

A method of promoting wound healing in a subject in need thereof, die method comprising:

• administering a therapeutically elective amount of a metal complex of Formula 1 and a pharmaceutically acceptable anion, wherein the metal complex of Formula 1 has the structure:
• wherein M is Ir (III) or Rh (III);
• each of Art1 and Ar2 is independently:
• wherein in for each instance is independently a whole number selected from 0-2;
• and
• R1 for each instance is independently selected from the group consisting of halide, nitro, nitrile, azido, —OR3, —OP(O)(OR3)2, —SR3, —N(R3)2, —P(O)(OR3)2, —C(O)R3, —C(O)OR3, —OC(O)R3, —N(R3)C(O)R3, —C(O)N(R3)2, —N(R3)C(O)OR3, —OC(O)N(R3)2, —OC(O)OR3, —N(R3)C(O)N(R3)2, —S(O)2R3, —S(O)2OR3, —S(O)2N(R3)2, —N(R3)S(O)2R3, alkyl, haloalkyl, perhaloalkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, aralkyl, and —(CR42)pA, wherein p for each instance is independently a whole number selected from 1-10;
• R4 for each instance is hydrogen, alkyl, cycloalkyl, aryl, or heteroaryl;
• and A for each instance is independently halide, nitrite, nitro, azido, —OR3, —SR3, —N(R3)2, —C(O)R3, —C(O)OR3, —OC(O)R3, —N(R3)C(O)R3), —C(O)N(R3)2, —N(R3)C(O)OR3, —OC(O)N(R3)2, —OC(O)OR3, —N(R3)C(O)N(R3)2, —S(O)2R3, —S(O)2N(R3)2, —N(R3)S(O)2R3, alkynyl, heterocycloalkyl, aryl, heteroaryl, and aralkyl;
• Ar3 is;
• wherein n for each instance is independently a whole number selected from 0-2;
• R2 for each instance is independently selected from the group consisting of halide, nitro, nitrile, azido, —OR3, —OP(O)(OR3)2, —SR3, —N(R3)2, —P(O)(OR3)2, —C(O)R3, —C(O)OR3, —OC(O)R3, —N(R3)C(O)R3, —C(O)N(R3)2, —N(R3)C(P)OR3, —OC(O)N(R3)2, —OC(O)OR3, —N(R3)C(O)N(R3)2, —S(P)2R3, —S(O)2OR3, —S(O)2N(R3)2, —N(R3)S(O)2R3, alkyl, haloalkyl, perhaloalkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, aralkyl, and —(CR42)pA, wherein p for each instance is independently a whole number selected from 1-10;
• R4 for each instance is selected from the group consisting of hydrogen, alkyl, cycloalkyl, aryl, and heteroaryl;
• or two instances of R4 taken together with the carbon to which they are bonded form a 3-6 membered cycloalkyl;
• and A for each instance is independently selected from the group consisting of halide, nitrile, nitro, azido, —OR3, —SR3, —N(R3)2, —C(O)R3, —C(O)OR3, —OC(O)R3, —N(R3)C(O)R3, —C(O)N(R3)2, N(R3)C(O)OR3, —OC(O)N(R3)2, —OC(O)OR3, —NR3)C(O)N(R3)2, —S(O)2R3, —S(O)2N(R3)2, —N(R3)S(O)2R3, alkynyl, heterocyeloalkyl, aryl, heteroaryl, and aralkyl;
• or two instances of R2 together with the carbons to which they are bonded form an optionally substituted 5-6 membered carbocycle;
• and
• R3 for each instance is independently hydrogen, alkyl, haloalkyl, perhaloalkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, or aralkyl;
• or two instances of R3 together with the atoms to which they are bonded form a 3-6 membered cycloalkyl or heterocycloalkyl.