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US 11,958,866 B1Granted
Synthesis of thiazole derivatives
AssigneeKing Faisal University
InventorsAwal Noor, Ezzat Khan, Umar Ali Khan
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Abstract
A synthetic protocol to use a thiourea or urea compound and auric chloride as starting materials to obtain thiazole and benzothiazole derivatives. The synthesis can be conducted at room temperature and the final compound can result from cyclization of the thiourea or urea compound in the presence of an Au salt from the auric chloride.
Claims10
A process for synthesizing a thiadiazole, the process comprising:
- preparing a first solution of a thiourea compound in acetonitrile;
- preparing a second solution of auric chloride (HAuCl4) in acetonitrile;
- adding the first solution to the second solution to obtain a reaction mixture;
- stirring the reaction mixture for at least six hours;
- filtering the reaction mixture to obtain a solid product;
- dissolving the solid product in chloroform to obtain a third solution;
- and
- recrystallizing the thiadiazole from the third solution;
- wherein the thiourea compound is 1-Benzoyl-3-(thiazole-2-yl)thiourea, the thiadiazole is N-(2H-thiazolo[3,2-b][1,2,4]thiadiazol-2-ylidene)benzamide, and the process comprises the following reaction:
6 more elements
A process for synthesizing a thiadiazole, the process comprising:
- preparing a first solution of a thiourea compound in acetonitrile;
- preparing a second solution of auric chloride (HAuCl4) in acetonitrile;
- adding the first solution to the second solution to obtain a reaction mixture;
- stirring the reaction mixture for at least six hours;
- filtering the reaction mixture to obtain a solid product;
- dissolving the solid product in chloroform to obtain a third solution;
- and
- recrystallizing the thiadiazole from the third solution;
- wherein the thiourea compound is 1-phenyl-3-(thiazole-2-yl)thiourea, the thiadiazole is 5-Methyl-N-phenyl-4λ4-[1,2,4]thiadiazolo[2,3-a]pyridine-2-aminegold(III) chloride, and the process comprises the following reaction:
6 more elements
Dependencies are inferred from the claim text.