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US 11,958,865 B1Granted
Leucine-rich repeat kinase 2 (LRRK2) inhibitors
AssigneeH. Lundbeck A/S
InventorsThomas Jensen, Thomas Andersen, Mikkel Jessing, Jacob Nielsen, Henrik Daver, Christopher Richard Jones
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Abstract
The present invention is directed to compounds of formula IIa These compounds are considered useful for the treatment of diseases associated with leucine-rich repeat kinase 2 (LRRK2) such as Parkinson's disease. Furthermore, the invention relates to pharmaceutical compositions comprising said compounds.
Claims19
A compound of formula IIa, or a pharmaceutically acceptable salt thereof, wherein:
- X is CH, CR1 or N;
- Y is CH, CR1 or N;
- R1 is independently selected from the group consisting of a C1-C3 alkyl, a C1-C3 haloalkyl, and a halogen;
- R2 is selected from a C1-C3 alkyl and an isotopically labelled C1-C3 alkyl;
- R3 is selected from the group consisting of a halogen, a cyano, and a C1-C3 haloalkyl;
- R4 is selected from the group consisting of a C1-C3 alkyl, an isotopically labelled C1-C3 alkyl, a C1-C3 haloalkyl, a O—C1-C3 alkyl, an isotopically labelled O—C1-C3 alkyl, a O—C1-C3 haloalkyl, and a O—C3-C6 cycloalkyl;
- n is 0, 1 or 2.
4 more elements
Dependencies are inferred from the claim text.