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US 11,958,864 B2Granted
Tetracyclic heterocycle compounds useful as HIV integrase inhibitors
AssigneeMerck Sharp & Dohme Corp.
InventorsTimothy John Hartingh, John A. McCauley, Tao Yu, Yonglian Zhang
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Abstract
The present invention relates to Tetracyclic Heterocycle Compounds of Formula (I): and pharmaceutically acceptable salts or prodrug thereof, wherein R1 is as defined herein. The present invention also relates to compositions comprising at least one Tetracyclic Heterocycle Compound, and methods of using the Tetracyclic Heterocycle Compounds for treating or preventing HIV infection in a subject.
Claims19
A compound having the formula (I):
- wherein:
- R1 is CHR2—O—C(O)—Y—R3, C(O)—C1-C10 alkyl, CHR2—O—P(O)(OH)2 or
- Y is a bond or —O—;
- R2 is hydrogen or C1-C6 alkyl;
- R3 is selected from the group consisting of C1-C6 alkyl, (CH2)x—O—C1-C6 alkyl, and (CH2)x—NR4R5, wherein said C1-C6 alkyl group can be optionally substituted with one to three groups independently selected from the group consisting of halo, hydroxy, methoxy and ethoxy;
- R4 is hydrogen or C1-C6 alkyl;
- R5 is hydrogen or C1-C6 alkyl;
- x is an integer from one to four;
- or a pharmaceutically acceptable salt thereof.
6 more elements
Dependencies are inferred from the claim text.