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US 11,958,858 B2Granted
Method for preparation of Asenapine
AssigneeZhejiang Ausun Pharmaceutical Co., Ltd.
InventorZhiguo Zheng
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Abstract
The present invention relates to a method for preparing Asenapine. In particular, the present invention relates to a method for preparing pharmaceutically acceptable Asenapine free base and new crystal form thereof, and also relates to methods for preparing the intermediate compounds used in said method.
Claims16
A method for preparing Asenapine of formula I, comprising the following step:
- wherein Intermediate IV is subjected to diazotization deamination reaction, and then purified by recrystallization to obtain Asenapine of formula I.
Dependencies are inferred from the claim text.