Pyrazole compounds, pharmaceutical compositions thereof and use thereof
AssigneeArtivila (Shenzhen) Innovation Center, Ltd.
InventorsChubiao Xue, Liye Huang, Hua Li, Tao Li, Huabin Liu
Life of this patent
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Abstract
Disclosed are pyrazole compounds represented by formula (I), pharmaceutical compositions containing such compounds, a method for preparing such compounds, and use of the pyrazole compounds and the pharmaceutical compositions. Such compounds are useful for inhibiting IRAK family kinases, and also useful for treating diseases caused by IRAK family kinases, such as autoimmune diseases, inflammatory diseases and cancers.
Claims18
A compound represented by Formula (I) or a pharmaceutically acceptable salt thereof, wherein the compound represented by Formula (I) has the following structure:
- wherein
- the Het ring is a five- or six-membered heteroaromatic ring;
- R1 is selected from H or D;
- R2 and R3 are each selected from H, D, alkyl, halogen, or ORa;
- R4 is selected from CORd, CONRbRc, CO2Rd, SO2Rd, or SO2NRbRc;
- R5 is selected from H, D, halogen, cyano, ORa, SRa, NRbRc, CORd, CONRbRc, CO2Rd, SO2Rd, SO2NRbRc, alkyl, alkenyl, alkynyl, cycloalkyl, or heterocycloalkyl;
- wherein the alkyl, alkenyl, alkynyl, cycloalkyl, or heterocycloalkyl is unsubstituted or substituted with 1 to 3 R5a;
- R5a is selected from H, D, halogen, cyano, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, ORa, SRa, NRbRc, CORd, CONRbRc, CO2Rd, SO2Rd, or SO2NRbRc;
- wherein the alkyl, cycloalkyl, or heterocycloalkyl is unsubstituted or substituted with 1 to 3 R5b;
- R5b is selected from H, D, halogen, cyano, ORa, SRa, NRbRc, CORd, CONRbRc, CO2Rd, SO2Rd, or SO2NRbRc;
- Ra, Rb, Rc, and Rd are each selected from H, D, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl, wherein the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl is unsubstituted or substituted with 1 to 4 R6;
- R6 is selected from H, D, halogen, cyano, ORa, SRa, NRbRc, NRbCORd, NRbCONRbRc, CONRbRc, CO2Rd, NRbSO2Rd, NRbSO2NRbRc, SORd, SO2Rd, SO2NRbRc, alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;
- wherein Rb and Rc in a group containing both Rb and Rc are attached to a N atom in the group by a single bond or form a heterocycloalkyl together with the N atom to which they are attached, and the heterocycloalkyl is unsubstituted or substituted with 1 to 3 R7;
- R7 is selected from H, D, halogen, cyano, ORa, SRa, NRbRc, NRbCORd, NRbCONRbRc, CONRbRc, CO2Rd, NRbSO2Rd, NRbSO2NRbRc, SORd, SO2Rd, SO2NRbRc, alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;
- and
- m, n, p, q, and y are each independently 1, 2, or 3.
Dependencies are inferred from the claim text.