Phenethylamine compounds salts, polymorphic forms and methods of use thereof
AssigneeTerran Biosciences Inc.
InventorSamuel Clark
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Abstract
Disclosed herein are salts and solid forms of MDMA, (R)-MDMA, (S)-MDMA, MDE, S-MDE, R-MDE, MDAI, MBDB, S-MBDB, R-MBDB, MEAI, and 5,6-Dimethoxy-2-aminoindane, including salts, solid forms of the compound and salts thereof, as well as polymorphs of solid forms. The solid forms disclosed herein may have improved properties, such as improved physical, chemical, and/or pharmacokinetic properties. Also disclosed are methods for making the salts and solid forms and methods for administering the same. The disclosed salt and solid forms of MDMA, (R)-MDMA, (S)-MDMA, MDE, S-MDE, R-MDE, MDAI, MBDB, S-MBDB, R-MBDB, MEAI, and 5,6-Dimethoxy-2-aminoindane may be useful for treating neurological disease and/or a psychiatric disorder in a subject.
Claims25
A solid form of 3,4-methylenedioxy-methamphetamine (MDMA) hemifumarate salt, wherein the solid form is characterized by two or three XRPD signals selected from the group consisting of 17.3° 2θ, 18.6° 2θ, and 21.9° 2θ (±0.2° 2θ;
- ±0.1° 2θ;
- or ±0.0° 2θ;
- Cu Kα1 radiation).
A solid form of 3,4-methylenedioxy-methamphetamine (MDMA) hemifumarate salt, wherein the solid form is characterized by two or three XRPD signals selected from the group consisting of 10.9° 2θ, 13.1° 2θ, and 16.7° 2θ (±0.2° 2θ;
- ±0.1° 2θ;
- or ±0.0° 2θ;
- Cu Kα1 radiation).
A solid form of 3,4-methylenedioxy-methamphetamine (MDMA) hemifumarate salt, wherein the solid form is characterized by two or three XRPD signals selected from the group consisting of 16.7° 2θ, 18.6° 2θ, and 21.8° 2θ (±0.2° 2θ;
- ±0.1° 2θ;
- or ±0.0° 2θ;
- Cu Kα1 radiation).
A solid form of 3,4-methylenedioxy-methamphetamine (MDMA) hemifumarate salt, wherein the solid form is characterized by two or three XRPD signals selected from the group consisting of 10.9° 2θ, 18.6° 2θ, and 21.9° 2θ (±0.2° 2θ;
- ±0.1° 2θ;
- or ±0.0° 2θ;
- Cu Kα1 radiation).
Dependencies are inferred from the claim text.